中国医药科学2015，Vol.5Issue(17)：96-98,3.
利拉鲁肽与二甲双胍合用对超重的2型糖尿病患者代谢指标的影响
Clinical efficacy of liraglutide combined with metformin in the treatment of obesity type 2 diabetes
李珊珊 1孙剑2
作者信息
- 1. 贵阳中医学院,贵州贵阳 550003
- 2. 内蒙古包头医学院第二附属医院内分泌科,内蒙古包头 014030
- 折叠
摘要
Abstract
Objective To study the therapeutic effects of the combination of Liraglutide and Metformin on obesity patients with type 2 diabetes(T2DM).Methods 40 obesity patients with type 2 diabetes whose blood glucose were not well controlled by taking oral metformin 3 months,given liraglutide and metformin therapy for 3 months.To explore abdomen circumference,the levels of fasting blood glucose,2h postprandial blood glucose,glycosylated hemoglobin,blood fat after treatment for 12 weeks.ResultsAfter 3 months treatment,HbA1c,FPG,2 hPG,HOMA-IR,low density lipoprotein cholesterol and BMI were reduced (P<0.05).HOMA-β were increased(P<0.05).Minority patients had nausea and discomfort of gastrointestinal symptoms within endurance.ConclusionCombination of liraglutide and metformin can significantly decrease blood glucose,reduce weight gain and serum lipid,improve insulin function which is a safe and effective therapy strategy for fatty type 2 diabetic patients.关键词
利拉鲁肽/二甲双胍/2型糖尿病Key words
Liraglutide/Obesity/Type 2 diabetes mellitus分类
医药卫生引用本文复制引用
李珊珊,孙剑..利拉鲁肽与二甲双胍合用对超重的2型糖尿病患者代谢指标的影响[J].中国医药科学,2015,5(17):96-98,3.
