中国医药科学2015，Vol.5Issue(17)：146-148,151,4.
乙型肝炎病毒pre S1与乙肝两对半和HBV DNA联合检测的临床价值分析
Clinical value analysis of combined detection of Hepatitis B Virus pre S1 protein antigen, five indexes of Hepatitis B and HBV DNA of patients with Hepatitis B in clinical diagnosis
叶远青 1罗文沈 1黄华 1梁红梅 1陈群 1杨联君 1鲍红霞1
作者信息
- 1. 深圳市龙岗区第二人民医院检验科,广东深圳 518112
- 折叠
摘要
Abstract
Objective To analyze the application value of combined detection of Hepatitis B Virus(HBV) pre S1 protein antigen,five indexes of Hepatitis B and HBV DNA of Patients with Hepatitis B in Clinical Diagnosis.Methods160 patients with Hepatitis B who were admitted to our hospital from April 2011 to April 2014 were selected as research subjects.Patients' serum samples in fasting condition were collected in the morning.Serum pre S1 and five indexes of Hepatitis B were detected by enzyme linked immunoassay and level of HBV DNA in serum was detected by fluorescent quantitative PCR at the same time.Results Positive rates of pre S1 antigen and HBV DNA of patients in the great three positive group was all significantly higher than other HBV-M models.The compared groups have significantly differences (P<0.05).Positive rates of pre S1 antigen in the HBeAg and HBcAb positive group was significantly higher than that in the small three positive group (P<0.05).Positive rate of HBV DNA in positive pre S1 antigen group was significantly higher than that in the negative pre S1 antigen group,of which,positive rate of HBV DNA in HBsAg+HBe Ag+HBcAb+pre S1+ group was highest and level of HBV DNA in this group was also highest.Among 146 HBsAg positive patients,137 were positive HBe Ag patients and positive rate of it was 93.8%.Positive rate of pre S1 antigen was 88.9% in HBeAg+ group which was significantly higher than that of HBeAg-group.These compared groups have significantly differences(P<0.05).100 HBV DNA cases were in positive HBsAg patients and the positive rate was 68.5%.Positive rate of pre S1 antigen in positive HBV DNA group was 85.0% which was significantly than that of HBV DNA- group.It suggested that there was a strong correlation between serum pre S1 and HBV DNA in positive HBsAg patients(P<0.05).Conclusion Combined detection of the three items can discover infection situation of Hepatitis B Virus as soon as possible to give instructions for diagnosis and treatment of patients.关键词
乙型肝炎病毒/前S1抗原/HBVDNA/联合检测/价值Key words
Hepatitis B Virus/Pre S1 antigen/HBV DNA/Combined detection/Value分类
医药卫生引用本文复制引用
叶远青,罗文沈,黄华,梁红梅,陈群,杨联君,鲍红霞..乙型肝炎病毒pre S1与乙肝两对半和HBV DNA联合检测的临床价值分析[J].中国医药科学,2015,5(17):146-148,151,4.
