摘要
Abstract
OBJECTIVE:To probe into the efficacy and safety of vinpocetine combined with tanshinoneⅡA sulfonic sodium in treatment of cerebral infarction.METHODS: 198 cases of patients with cerebral infarction admitted into People's Hospital of Jiangxi Shicheng County from Jan.2009 to Jun.2014 were divided into the observation group and the control group via random number table, with 99 cases in each group.The control group received tanshinoneⅡA sulfonic sodium injection (40-60 mg, ivgtt, qd) with 0.9% sodium chloride 250 ml; and the observation group were treated with vinpocetine (20-30 mg, ivgtt, qd) based on the control group.The indexes of neurologic impairment score, activities of daily living score, efficacy, coagulation parameters and blood platelet count, prognosis and adverse reactions in two groups were observed.RESULTS:After treatment of 14d and 30d, the neurologic impairment score of observation group were respectively (5.1 ±2.8) scores and (3.7 ±2.2) scores, significantly lower than that of the control group (7.8 ±5.2 ) scores and ( 6.2 ±4.3 ) scores.After treatment of 14 d and 30 d, activities of daily living score of observation group were respectively (42.3 ±22.1) scores and (67.2 ±28.6) scores, significantly higher than that of the control group (29.4 ±17.5) scores and (46.3 ±23.7) scores,with statistically significant difference (P<0.05).The total effective rate of observation group was 96.97%, significantly higher than that of control group 90.91%, with statistically significant difference ( P<0.05 ) .After treatment of 14 d, the coagulation parameters and blood platelet count of observation group were obviously better than that of control group, the difference was statistically significant (P<0.05).CONCLUSIONS:The efficacy of vinpocetine combined with tanshinoneⅡA sulfonic sodium in treatment of cerebral infarction is precise and safe, it is worthy of clinical promotion.关键词
长春西汀/丹参酮ⅡA磺酸钠/脑梗死/临床研究Key words
Vinpocetine/TanshinoneⅡA sulfonic sodium/Cerebral infarction/Clinical study分类
医药卫生
