中国执业药师Issue(11)：31-34,4.DOI:10.3969/j.issn.1672-5433.2015.11.007
参龙散结丸（浓缩丸）的质量标准研究
Study on Quality Standards for Shenlong Sanjie Pills
摘要
Abstract
Objective: To establish the quality standards for shenlong sanjie pills . Methods: rhizoma atractylodis macrocephalae , chinaroot greenbrier and spica prunellae in shenlong sanjie pills were identified by TLC and the content of hesperidin in shenlong sanjie pills was determined by HPLC. The column of YMC-Pack ODS-A C18 (150 mm × 4.6 mm,5 μm)was used with a mobile phase of methanol-acetic acid-water (35∶4∶61), the column temperature was at 30 ℃, the flow rate was 1 . 0 mL/min and the detection wavelength was at 283 nm . Results: Rhizoma atracty-lodis macrocephalae , chinaroot greenbrier and spica prunellae were tested and the TLC spots were clear , there was no interference in negative control . A good linear relationship was showed between the peak area and hesperidin reference sample size in the range of 0.044 34~1.108 5 μg, (r = 0.999 9). The average recovery was 96.88%, RSD = 1 . 49% ( n = 6 ) . Conclusion: TLC qualitative identification of rhizoma atractylodis macrocephalae , china-root greenbrier and spica prunellae in shenlong sanjie pills was specific . The method for the quantitative determina-tion of hesperidin by HPLC is accurate , reproducible and applicable to the quality control of shenlong sanjie pills .关键词
参龙散结丸(浓缩丸)/质量标准/高效液相色谱/薄层色谱Key words
Shenlong Sanjie Pills/Quality Standard/HPLC/TLC引用本文复制引用
赖杰仁,杨毅生..参龙散结丸（浓缩丸）的质量标准研究[J].中国执业药师,2015,(11):31-34,4.基金项目
江西省卫生计生委中医药科研计划项目 （）
