中国中医药信息杂志Issue(8)：29-31,3.DOI:10.3969/j.issn.1005-5304.2013.08.011
四逆汤组方配伍减毒实验研究
Experimental Study on Toxicological Interaction of Ingredients in Sini Decoction
摘要
Abstract
Objective The toxicological compatibility of Aconiti Carmichaeli Radix, as a toxic Chinese medicinal herb, combined with the other ingredients in Sini Decoction was investigated to elucidate the rationality of the combination of the ingredients in Sini Decoction from toxicological point of view. Methods Three kinds of experiments, acute toxicity in mice, heart toxicity in rats and aconitines level in water extract of Sini Decoction and its ingredients including Aconiti Carmichaeli Radix alone and its combination with licorice or dried ginger were adopted in this study. In the toxicological experiments, LD50 values for the acute toxicity test and TD50 values for the heart toxicity (arrhythemia as a parameter) of Sini Decoction, Aconiti Carmichaeli Radix alone and its combination with licorice or dried ginger were comparatively determined. And levels of individual aconitines of the water extracts from Sini Decoction, Aconiti Carmichaeli Radix alone and its combination with licorice or dried ginger were measured, respectively. Results The LD50 and TD50 of the combination of Aconiti Carmichaeli Radix and licorice in Sini Decoction were found to be higher than Aconiti Carmichaeli Radix alone or Sini Decoction, while the LD50 and TD50 of the combination of Aconiti Carmichaeli Radix and dried ginger appeared to be not different from those of Aconiti Carmichaeli Radix alone. The level of the main toxic compound of the water extracts for the combination of Aconiti Carmichaeli Radix and licorice, and Sini Decoction was lower than that of Aconiti Carmichaeli Radix alone and its combination with dried ginger. Conclusion The combination of Aconiti Carmichaeli Radix and licorice can attenuate the toxicity of Aconiti Carmichaeli Radix.关键词
四逆汤/配伍减毒/附子/动物模型Key words
Sini Decoction/compatibility for attenuation/Aconiti Carmichaeli Radix/animal model分类
医药卫生引用本文复制引用
张广平,朱晓光,孟贺,张思玉,杨海润,叶祖光..四逆汤组方配伍减毒实验研究[J].中国中医药信息杂志,2013,(8):29-31,3.基金项目
国家重点基础研究发展计划(2009CB522806) （2009CB522806）
