中国中医药信息杂志Issue(9)：52-54,3.DOI:10.3969/j.issn.1005-5304.2013.09.018
复方熊胆茵陈颗粒质量标准研究
Study on Quality Standard of Fufang Xiongdan Yinchen Granule
摘要
Abstract
Objective To establish the quality standard for Fufang Xiongdan Yinchen Granule. Methods TLC was employed to identify Pulvis ellis urs, Capillary Wormwood Herbin, Atractylodis Macrocephalae Rhizoma and Glycyrrhizae Radix, and HPLC was used to determine the content of sodium tauroursodeoxycholic acid in Fufang Xiongdan Yinchen Granule. Kromail 100-5 C18 column (4.6 mm× 250 mm, 5 µm) in an oven at 25 ℃ was need, with a mobile phase consisting of methanol-0.03 mol/L sodium dihydrogen phosphate solution (60∶40, pH=4.4) and UV detector at 210 nm, the flow rate was 1.0 mL/min. Results Pulvis ellis urs, Capillary Wormwood Herbin, Atractylodis Macrocephalae Rhizoma and Glycyrrhizae Radix can be detected by TLC. The linearity of sodium tauroursodeoxycholic acid was obtained in the range of 0.182 1-1.821 mg (r=0.999 98). The average recovery was 100.39%, and RSD was 1.70% (n=6). Conclusion The method is simple, accurate, specific, and can control the quality of Fufang Xiongdan Yinchen Granule effectively.关键词
复方熊胆茵陈颗粒/质量标准/薄层色谱法/高效液相色谱法Key words
Fufang Xiongdan Yinchen Granule/quality standard/TLC/HPLC分类
医药卫生引用本文复制引用
李煌,徐伟,郑海音,洪振丰,许舒瑜..复方熊胆茵陈颗粒质量标准研究[J].中国中医药信息杂志,2013,(9):52-54,3.基金项目
福建省科技重大专项(2010YZ0001-1)；福建省教育厅项目(JA11139) （2010YZ0001-1）
