中国中医药信息杂志2015，Vol.22Issue(11)：13-15,3.DOI:10.3969/j.issn.1005-5304.2015.11.004
加味黄芪桂枝五物汤外洗治疗奥沙利铂致周围神经病变临床研究
Clinical Study on External Bath of Modified Huangqi Guizhi Wuwu Decoction for Peripheral Neurotoxicity Induced by Oxaliplatin
摘要
Abstract
Objective To observe clinical efficacy of external bath of modified Huangqi Guizhi Wuwu Decoction in relieving peripheral neurotoxicity induced by oxaliplatin.Methods Sixty patients were randomly divided into control group and treatment group (30 cases in each group). Both groups received intramuscular injection of mecobalamine (0.5 mg/d, three times a week). At the same time, the treatment group received external bath of modifiedHuangqi Guizhi Wuwu Decoction. All the courses of treatment lasted for 14 days. Clinical efficacy and adverse reactions of the two groups were observed.Results The total effective rate of treatment group was 73.3% (22/30), which was superior to that of 40.0% (12/30) in the control group, with statistical significance (P<0.05), without any adverse reaction.Conclusion External bath of modifiedHuangqi Guizhi Wuwu Decoction is effective as supportive care for alleviating chronic peripheral neurotoxicity induced by oxaliplatin.关键词
奥沙利铂/周围神经病变/黄芪桂枝五物汤Key words
oxaliplatin/peripheral neurotoxicity/Huangqi Guizhi Wuwu Decoction分类
医药卫生引用本文复制引用
沈婕,何胜利,孙贤俊,胡南华,蔡芸芸..加味黄芪桂枝五物汤外洗治疗奥沙利铂致周围神经病变临床研究[J].中国中医药信息杂志,2015,22(11):13-15,3.基金项目
上海市闵行区科委基金项目(2013MHZ047) （2013MHZ047）
上海市第三批中医临床优势专科(专病)建设项目(ZYSNXD-YL-YSZK025) （专病）
