中国卒中杂志Issue(3)：171-176,6.
3.0T高分辨磁共振研究大脑中动脉粥样硬化性狭窄重构模式
Remodeling Pattern of Atherosclerotic Middle Cerebral Artery Stenosis on 3.0T High-Resolution Magnetic Resonance Imaging
摘要
Abstract
Objective To investigate the remodeling pattern of symptomatic atherosclerotic middle cerebral artery(MCA) stenosis with 3.0T high-resolution magnetic resonance imaging(HRMRI). Methods Eighty-seven consecutive patients with symptomatic atherosclerotic stenoses at M1 segment of MCA on digital subtraction angiography(DSA)(50%-99%) were enrolled from November 2009 to May 2011. HRMRI was performed on the target segment by using a 3.0T MR scanner. Remodeling index(RI) was calculated as vessel area at maximal lumen narrowing(MLN)/reference vessel area. RI≤0.95 was defined as negative remodeling(NR), RI≥1.05 as positive remodeling(PR), and 0.95>RI<1.05 as intermediate remodeling(IR). Wall characteristics were compared between the NR and PR group. Results Seventy patients were included in the final analysis, and NR was found in 29(41.4%) patients, IR in 6(8.6%) patients, and PR in 35(50.0%) patients. At MLN sites, compared with lesions with PR, lesions with NR had a less wall area([11.5±3.0]mm2 vs [16.6±4.5]mm2, P﹤0.001), and percent plaque burden([9.5±17.3]%vs [42.3±11.0]%, P﹤0.001). Conclusion HRMRI can help assess the remodeling pattern of MCA stenosis. In patients with MCA atherosclerotic stenosis, NR lesions are also frequently observed and have a less wall area and plaque burden than PR lesions.关键词
动脉粥样硬化/大脑中动脉/重构指数/磁共振成像/高分辨Key words
Atherosclerosis, Middle cerebral artery/Remodeling index/High resolution magnetic resonance imaging引用本文复制引用
朱先进,王春雪,姜卫剑,杜彬,金旻,娄昕,马林..3.0T高分辨磁共振研究大脑中动脉粥样硬化性狭窄重构模式[J].中国卒中杂志,2013,(3):171-176,6.基金项目
国家自然科学基金课题(81071115)国家重点基础发展计划(973计划)(2013CB733805)国家自然科学基金课题(30670731 （81071115）
81070925)国家自然科学基金课题(81101034) （81101034）
