中国卒中杂志Issue(8)：614-621,8.
皮质下缺血性血管病患者联络纤维的扩散张量成像分析和认知功能相关研究
Diffusion Tensor Imaging Analysis of Association Fibers in Patients with Subcortical Ischemic Vascular Disease and Correlations with Cognitive Function
林霖 1薛蕴菁 1段青 1康正武 1林海龙 1孙斌1
作者信息
- 1. 350001 福州福建医科大学附属协和医院放射科
- 折叠
摘要
Abstract
Objective To investigate microstructure changes of association fibers in subcortical ischemic vascular disease (SIVD) patients using atlas-based analyses (ABA) of diffusion tensor imaging (DTI) and clinical correlations of ischemic changes. <br> Methods Forty SIVD patients (18 vascular cognitive impairment [VCI] patients and 22 non-cognitive impairment [NCI] patients) and 20 normal controls were performed with neuropsychological tests and 3-Tesla magnetic resonance imaging (MRI) including DTI scans. The rating score of white matter change, ABA of the fractional anisotropy (FA) and mean diffusivity (MD) were computed. The correlation between DTI parameters and Montreal Cognitive Assessment (MoCA) scores were evaluated. <br> Results Compared with NCI group, VCI group patients had lower FA value and higher MD value in bilateral sagittal stratum (inferior longitudinal fasciculus/inferior fronto-occipital fasciculus), cingulate gyrus (cingulum), hippocampus (cingulum), superior longitudinal fasciculus, superior fronto-occipital fasciculus, uncinate fasciculus. However, the rating score of white matter change showed no signiifcant difference. In addition, MoCA scores of SIVD patients positively correlated with FA values and negatively correlated with MD values of association ifbers, including bilateral sagittal stratum (inferior longitudinal fasciculus/inferior fronto-occipital fasciculus), cingulate gyrus (cingulum), superior longitudinal fasciculus, superior fronto-occipital fasciculus, uncinate fasciculus and left hippocampus (cingulum). <br> Conclusion FA values increase and MD values decrease in association ifbers of SIVD patients. Moreover, it is signiifcantly related with cognitive function.关键词
皮质下缺血性血管病/扩散张量成像/联络纤维/认知Key words
Subcortical ischemic vascular disease/Diffusion tensor imaging/Association ifbers/Cognition引用本文复制引用
林霖,薛蕴菁,段青,康正武,林海龙,孙斌..皮质下缺血性血管病患者联络纤维的扩散张量成像分析和认知功能相关研究[J].中国卒中杂志,2013,(8):614-621,8.
