中国卒中杂志Issue(10)：822-826,5.DOI:10.3969/j.issn.1673-5765.2015.10.003
脑微出血与脑白质病变及腔隙性梗死关系研究
Relationship between Cerebral Microbleeds and White Matter Lesions and Lacunar ;Infarcts
摘要
Abstract
Objective To investigate the relationship between cerebral microbleeds(CMBs) and white matter lesions(WML) and lacunar infarcts(LI). Methods The identiifed population inculded 217 patients with cerebral vascular disease or related risk factors admitted to the Department of Geriatric Neurology of the PLA General Hospital between February, 2010 and February, 2012. Routine sequence and T2 star weighted angiography sequence of magnetic resonance imaging were performed with 1.5 Tesla machine maded by General Electric company. The number of CMBs in deep and cortical brain was record respectively. The peri-ventricular hyperintensities(PVH) and deep white matter hyperintensities(DWMH) were scored by Fazekas scale and modiifed rating scale reviesd by Scheltens. The severity of LI was classiifed by the number. Results As the score of PVH and DWMH increased, the detection rate of CMBs obviously increased from 41.8%and 40.8%in patient with the severity of PVH=1 and DWMH=1 to 68.8%and 76.9%in patient with the severity of PVH=3 and DWMH=3. The detection rate of CMBs also rised with the number of LI increasing. Deep CMBs were closely related to severity of peri-ventricular and deep WML (rs=0.345, P<0.001;rs=0.346, P<0.001), and were also related to LI (rs=0.281, P<0.001). Cortical CMBs were mildly related to severity of peri-ventricular WML and deep WML (rs=0.219, P=0.001;rs=0.189, P=0.005), and were not related to LI. Conclusion Deep cerebral microbleeds are obviously associated with peri-ventricular and deep white matter lesions and lacunar infarcts.关键词
脑微出血/脑小血管病/脑白质病变/腔隙性梗死Key words
Cerebral microbleeds/Cerebral small vessel disease/White matter lesions/Lacunar infarcts引用本文复制引用
高中宝,赵杏丽,王振福,杨扬,管锦群,王婷,吴卫平..脑微出血与脑白质病变及腔隙性梗死关系研究[J].中国卒中杂志,2015,(10):822-826,5.基金项目
中央保健专项资金科研课题（B2009B104）解放军总医院临床扶持基金 （）
