中华耳科学杂志Issue(1)：104-106,3.DOI:10.3969/j.issn.1672-2922.2013.01.024
高强度低频噪声对豚鼠听力及耳蜗毛细胞的影响
Effects of Low Frequency Noise at High Levels on Hearing and Cochlear Hair Cells in Guinea Pigs
王建军 1冯勃2
作者信息
- 1. 浙江省临海市耳鼻咽喉研究所浙江 317016
- 2. 中国人民解放军总医院耳鼻咽喉科研究所北京 100853
- 折叠
摘要
Abstract
Objective To study the effect of low frequency noise at high levels on hearing. Methods Guinea pigs (250~300 g) with normal hearing, were exposed to a 130 dB SPL band noise centered around 100 Hz continuously for 4 hours. The auditory brainstem response was recorded and cochlear morphology examined immediately and at 1 day after the exposure. Results The exposure produced about 20 dB temporary threshold shift. After 1 day, there were signs of hearing recovy, but thresholds remained elevated. On morphology examination, although there was no significant injury to cochlear hair cells, early apoptosis protein Caspase3 was detected. Conclusion Low frequency noise at high levels can produce tem⁃porary threshold shift, but quickly followed by partial recovery. Although cochlear hair cells show no signs of damage imme⁃diately, there are indications that the apoptotic process may have been activated.关键词
低频噪声/耳蜗/损伤/豚鼠Key words
low frequency noise/cochlea/damage/guinea pig分类
医药卫生引用本文复制引用
王建军,冯勃..高强度低频噪声对豚鼠听力及耳蜗毛细胞的影响[J].中华耳科学杂志,2013,(1):104-106,3.
