中华耳科学杂志Issue(2)：256-258,3.DOI:10.3969/j.issn.1672-2922.2013.02.021
鼻咽癌放疗后并发分泌性中耳炎的临床分析
Secretory Otitis Media after Radiotherapy for Nasopharyngeal Carcinoma
张明洁 1刘业海 2李慧 1陈德尚 1韩跃峰1
作者信息
- 1. 安徽省蚌埠医学院第一附属医院耳鼻咽喉头颈外科 233004 蚌埠
- 2. 安徽省安徽医科大学第一附属医院耳鼻咽喉头颈外科 230000 合肥
- 折叠
摘要
Abstract
Objective This study was to study the incidence of secretory otitis media among patients with nasopharyn-geal carcinoma (NPC) after radiotherapy and potential influencing factors. Methods Clinical data of 127 NPC patients treat-ed at the First Affiliated Hospital of Bengbu Medical College from 2007 to 2010 were retrospectively analyzed. The incidence of secretory otitis media and possible contributing factors were assessed. Results Of the 116 NPC patients without secretory otitis media before radiotherapy, 91.3%(116/127) developed secretory otitis media after radiotherapy. The occurrence rates of secretory otitis media at 3, 6, 12 and 18 months after radiotherapy were 11.8%(15/127) , 29.1%(37/127) , 46.5%(59/127) and 3.9%(5/127), respectively (χ2=71.23, P<0.001). The Incidence of SOM was higher among stage T3+T4 patients (79 cas-es) than among stage T1+T2 patients (48 cases), (96.2%vs 83.3%,χ2=4.73, P=0.030). The secretory otitis media was 86.5%(64/74) among patients who were given radiotherapy at 70-Gy or less, and 98.1%(52/53) among those whose radiation doses was more than 70-Gy (χ2=3.91,P=0.048). The incidence of secretory otitis media in patients with pharyngeal orifice audito-ry tube infringement was 98.2%(56/57), higher than in others (85.7%, 60/70) (χ2=4.75, P=0.029). Conclusion The inci-dence of secretory otitis media in NPC patients after radiotherapy is high and reaches a peak in one year. It is influenced by invasion of pharyngeal orifice auditory tube, the dose of radiotherapy and T stage.关键词
鼻咽肿瘤/放射疗法/并发症/分泌性中耳炎/影响因素Key words
Nasopharyngeal neoplasm/radiotherapy/complication/secretoryotitis media(som)/influencing factors分类
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张明洁,刘业海,李慧,陈德尚,韩跃峰..鼻咽癌放疗后并发分泌性中耳炎的临床分析[J].中华耳科学杂志,2013,(2):256-258,3.
