中华耳科学杂志Issue(2)：284-287,4.DOI:10.3969/j.issn.1672-2922.2013.02.029
慢性不可预见性温和刺激大鼠模型的听性脑干反应的改变
ABR Changes in a Rat Model of CUMS Induced Depression
摘要
Abstract
Objective To study changes of auditory brainstem response (ABR) in a rat model of depression induced by chronic unpredictable mild stress (CUMS). Methods Sixteen rats were randomly divided into a control group (n=8) and a mod-el group (n=8). The model group was randomly treated with CUMS every day to keep animals in a depressive state for 28 days. Animal behaviors were recorded using an automatic tracking system at 1 day before experiment and on Days 14 and 28. In the present study, ABRs were tested using a TDT system on Day 28 for all animals. Results Compared with the control group, the basic indices of animal behavior of the model group were markedly different from the control group on Days 14 and 28 (p<0.01), indicating successful modeling, although there was no statistical difference on ABR thresholds between the two groups (P>0.05). The latencies of waves I and V in the model group were significantly longer than the control group (P<0.05) and the amplitudes of waves II and V were markedly decreased compared to the control group (P<0.05 and P<0.01, respectively). Con-clusion Abnormal neuroelectric activities along the auditory pathway from the peripheral auditory organ to the brainstem may exist in rats with CUMS induced depression .关键词
抑郁症/慢性应激/听性脑干反应Key words
Depression/CUMS/Auditory brainstem response分类
医药卫生引用本文复制引用
陈抗松,廖华,杨希林,陈建新..慢性不可预见性温和刺激大鼠模型的听性脑干反应的改变[J].中华耳科学杂志,2013,(2):284-287,4.基金项目
国家自然科学基金面上项目（30772397）资助。 （）
