中华耳科学杂志Issue(3)：393-397,5.DOI:10.3969/j.issn.1672-2922.2015.03.003
早期糖尿病儿童听力学状况初步研究
A preliminary audiology study in children with early diabetes
刘薇 1葛文彤 1陈敏 1张杰 1李靖 1刘海红 1吴迪 2郝津生 1杨杨 1张亚梅 1刘世琳1
作者信息
- 1. 首都医科大学附属北京儿童医院耳鼻咽喉头颈外科北京市儿科研究所儿童耳鼻咽喉头颈外科疾病北京市重点实验室 北京，100045
- 2. 首都医科大学附属北京儿童医院内分泌科 北京，100045
- 折叠
摘要
Abstract
Objective This is a comprehensive audiology examination on children with diabetes aimed to determine if diabetes affected their hearings. Methods Data from 40 children with diabetes seen at Beijing Chil-dren’s Hospital from January to May in 2015 were collected, including clinical information and comprehen-sive audiology examination (e.g. ABR, ASSR, DPOAEs, pure tone audiometry and acoustic immittance). Mito-chondrial genes were also tested in a patient with family history of hearing loss. Results Of the 40 patients, 16 were male and 24 were female, aged from 0.4 to 17.8 years (median=10 years). The course of disease was 2–1642 days (median=30 days). HbA1c level at the time of audiology testing was 6.2-18.8%. Audiology re-sults were within normal limits in all patients except one child with reported hearing loss and family history of diabetes, whose genetic tests showed mitochondrial tRNA leu (uur) A3243G mutation in blood (mutation ra-tio=42.8%) and urine (mutation ratio=83.2%) and was diagnosed with mitochondrial diabetes. ABR wave V latency and I-V interpeak latency in children with normal HbA1C and urine trace albumin were different from those showing abnormal results (P<0.05). Conclusion Children with diabetes of less than 5 years appear to car-ry subclinical hearing change, that is related to blood glycemic control and probably represents early peripheral organ damage. Genetic testing is important in children with reported hearing loss and family history of diabetes to identify mitochondrial diabetes.关键词
糖尿病/听力损失/基因突变Key words
diabetes/hearing loss/gene mutation分类
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刘薇,葛文彤,陈敏,张杰,李靖,刘海红,吴迪,郝津生,杨杨,张亚梅,刘世琳..早期糖尿病儿童听力学状况初步研究[J].中华耳科学杂志,2015,(3):393-397,5.
