中华耳科学杂志Issue(3)：403-406,4.DOI:10.3969/j.issn.1672-2922.2015.03.005
万古霉素对幼儿听力的影响研究
Effects of Vancomycin on Hearing in Young Children
杨扬 1周怡 1张杰 1刘冰 1刘海红 1张亚梅 1刘世琳 1张晓絮 1陈敏1
作者信息
- 1. 首都医科大学附属北京儿童医院耳鼻咽喉头颈外科儿童耳鼻咽喉头颈外科疾病北京市重点实验室 北京100045
- 折叠
摘要
Abstract
Object To determine whether vancomycin affects hearing in children. Methods Twenty two children diagnosed with acute infection were treated with vancomycin at Beijing Children’s Hospital Infec-tious Disease Department from January 2014 to June 2014. Patients’hearing was tested using auditory brain-stem responses (ABR) before and after vancomycin treatment. Relations between treatment course, co-adminis-tered medications, liver and/or kidney functions and hearing results were analyzed using paired t test or rank-sum test, with P<0.05 representing statistical significance. Results In the 22 patients (aged from 2 months to 59 months with a median age of 28 months), ABR thresholds at 4 kHz, latencies of wave I, III and V and the I-V interpeak latency showed no statistically significant differences before and after vancomycin treat-ment, or when compared between those treated with (n=13) or without (n=9) additional co-administered medi-cations. Nor did hearing show statistically significant differences when compared between patients with (n=8) or without (n=14) co-existing abnormal liver and/or kidney functions. No significant difference in hearing was seen between patients treated for less than 10 days (n=12) and those treated beyond 10 days (n=10). Conclu-sion 1) The use of vancomycin has no damaging effects on hearing in young children over short term. 2) How-ever, potentially increased risks for hearing damage associated with co-administration of medications, pro-longed duration of treatment or abnormal live/kidney functions may need further studies.关键词
万古霉素/听力学/儿童Key words
Vancomycin/Audiology/Children分类
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杨扬,周怡,张杰,刘冰,刘海红,张亚梅,刘世琳,张晓絮,陈敏..万古霉素对幼儿听力的影响研究[J].中华耳科学杂志,2015,(3):403-406,4.
