王鸿南 1吴玮 1韩浩伦 1李保卫 1王刚 1姚晓琳 1屈昌北 1丁瑞英1
作者信息
- 1. 北京解放军306医院耳鼻咽喉科头颈外科 北京100101
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摘要
Abstract
Object To study the effects of changes in stimulus frequency difference on mismatch negativi-ty (MMN) in normal people, the mechanism of MMN generation, and the pragmatic value of MMN as a tool in evaluating sound discrimination capability. Methods MMN tests were performed on 9 young males. In all cas-es, acoustic brainstem responses (ABRs) were tested first to identify ABR thresholds. MMN was tested under the condition of reading. The odd-ball model was used, and a brief pure tone was used as the stimulus. Frequen-cy deviation was given at a rate of 20%, while the standard frequency at a rate of 80%. The stimulus was deliv-ered at 50 dB above the ABR threshold at a rate of 1.1/sec. Each subject received four MMN tests for the devi-ated frequency of 750, 1000, 2000 and 3000 Hz, with the corresponding standard frequency at 500, 500, 1000 and 1000 Hz, respectively, yielding a frequency difference magnitude (DM) of 250, 500, 1000 and 2000 Hz, in each test. The latency and amplitude of MMN were analyzed. Results In all cases, ABR thresholds were≤25 dB nHL and MMN was successfully induced and recorded. For the DM of 250, 500, 1000 and 2000 Hz, the la-tency was 167.61±14.93 ms, 148.48±12.03 ms, 139.17±10.93 ms and 121.37±19.51 ms, respectively (F=18.81, p=0.000), with corresponding amplitudes of 5.62±2.68 uV, 7.35±2.97 uV, 6.13±1.83 uV and 6.36±2.26uV (F=0.956, p=0.397). Conclusion MMN can be consistently induced in normal young people. With increasing DM, the MMN latency shows a systematic reduction with no obvious change in MMN amplitude. The phenomenon is highly reproducible. MMN, as an effective tool to test sound discrimination capability, has a prospective clin-ical pragmatic value.关键词
失匹配负波/听力学/声音辨别/听觉中枢Key words
Mismatch Negativity (MMN)/Sound Discrimination/Auditory Center/Audiology/Normal People分类
医药卫生
