中华肝脏外科手术学电子杂志Issue(5)：311-313,3.DOI:10.3877/cma.j.issn.2095-3232.2015.05.013
应用他克莫司治疗的肝移植术后患者凝血功能变化及意义
Changes of coagulation function in patients when using tacrolimus after liver transplantation and its signiifcance
摘要
Abstract
ObjectiveTo investigate the changes of coagulation function in patients receiving tacrolimus immunotherapy after liver transplantation and its significance.MethodsClinical data of 63 patients undergoing liver transplantation in the Third Afifliated Hospital of Sun Yat-sen University between May 2012 and December 2014 were retrospectively studied. Among the 63 patients, 51 were males and 12 were females with the average of (45±15) years old. The informed consents of all patients were obtained and the local ethical committee approval had been received. The triple medication regimen of tacrolimus + mycophenolate mofetil + adrenocortical hormone was utilized. Prothrombin time (PT), ifbrinogen (Fib), activated partial thromboplastin time (APTT), thrombin time (TT) and platelets count (Plt) were tested before surgery, on the day of surgery and on 1-5 d after surgery. The comparisons of the data were conducted usingt test.ResultsThe average Plt before surgery was (104±37)×109/L and the average Plt on 1-5 d after surgery was respectively (73±21)×109/L, (60±19)×109/L, (64±20)×109/L, (50±17)×109/L and (52±17)×109/L, and signiifcant difference was observed (t=-3.768,-4.462,-4.584,-2.048,-2.934;P<0.05). The other coagulation function indexes (PT, Fib, APTT and TT) were gradually improved when compared with those before surgery. ConclusionDuring the recovery of coagulation function after liver transplantation, continuous Plt decrease may occur. Plt changes should be on alert when tacrolimus is used.关键词
肝移植/血小板/他克莫司结合蛋白质类Key words
Liver transplantation/Blood platelets/Tacrolimus binding proteins引用本文复制引用
徐长志,林维真,李晓杰,胡波..应用他克莫司治疗的肝移植术后患者凝血功能变化及意义[J].中华肝脏外科手术学电子杂志,2015,(5):311-313,3.基金项目
广东省自然科学基金 （）
