浙江医学Issue(1)：6-9,4.
血清骨保护素水平与慢性冠心病的相关性研究
Relationship between serum osteoprotegerin and coronary heart disease
摘要
Abstract
Objective To investigate the relationship of serum osteoprotegerin and receptor activator of nuclear factor kappaβ ligand (RANKL) levels with chronic coronary heart disease. Methods Serum OPG and RANKL levels were measured by ELISA in 80 patients with chronic coronary heart disease and 34 healthy subjects. Relationship of OPG and RANKL with coro-nary stenosis and calcification was analyzed by SPSS. Results The serum levels of OPG and RANKL in patients group was sig-nificant higher than those in control group (P<0.01,P<0.05). The OPG and RANKL levels were significantly higher in patients with more than one coronary branches stenosis than those with one branch stenosis or no stenosis (P<0.01,P<0.05). The OPG levels in patients with moderate and severe stenosis, the RANKL levels in patients severe stenosis were significantly higher than those in control group(P<0.01) and those in patients with mild stenosis(P<0.01, P<0.05). The level of OPG in patients with coronary cal-cified plaques was significantly higher than those with mixed or soft plaques(P<0.05). Conclusion OPG and RANKL are closely correlated with the stenosis and calcification of coronary artery, indicating that measurement of serum OPG and RANKL levels may reflect the stenosis, calcification and injury of coronary arteries.关键词
冠心病/骨保护素/核因子κβ受体活化因子配体/冠状动脉狭窄/冠状动脉钙化Key words
Coronary heart disease/Osteoprotegerin/Recepor activator of nuclear factor kappaβligand/Coronary stenosis/Coronary calcification引用本文复制引用
翁秀妹,叶雄伟,王强,周欢琴..血清骨保护素水平与慢性冠心病的相关性研究[J].浙江医学,2013,(1):6-9,4.
