浙江医学Issue(1)：14-15,19,3.
间歇缺氧大鼠 NF-kBp65以及MCP-1的表达
Express of NF-kB65 and MCP-1 in intermittent hypoxia rats
摘要
Abstract
Objective To investigate the expression of NF-kBp65 and MCP-1 in serum and heart muscle in intermittent hypoxia rats. Methods There are thirty SD rats were randomly assigned into three groups: control group, intermittent hypoxia group and continuing hypoxia group, which were exposed to air, intermittent hypoxia and continuing hypoxia respectively 8h/d for 35d.Then the blood and heart samples were collected, and the NF-kBp65 and MCP-1 levels in serum and in heart tissue were measured with ELISA and Western blot respectively. Results Compared to the control group the contents of NF-kBp65 and MCP-1 in serum and heart were increased both in intermittent hypoxia group and continuing hypoxia group. Conclusion NF-kBp65 and MCP-1 in heart and blood of intermittent hypoxia rats, which may be associated with the activation of NF-kB by hypoxia.关键词
缺氧/心肌/NF-kBp65/MCP-1/大鼠Key words
Hypoxia/Heart muscle/NF-kBp65/MCP-1/Rats引用本文复制引用
徐晓梅,樊荣,黄晓颖,林乾顶,王良兴..间歇缺氧大鼠 NF-kBp65以及MCP-1的表达[J].浙江医学,2013,(1):14-15,19,3.基金项目
温州市科技局资助项目(Y20090125) （Y20090125）
