浙江医学Issue(1)：29-31,40,4.
急性脑梗死患者血清 PD-ECGF和 VEGF 的动态变化
Dynamic changes of platelet derived endothelial cell growth factor and vascular endothelial growth factor in the serum of patients with acute cerebral infarction
摘要
Abstract
Objective To investigate the dynamic changes of platelet derived endothelial cel growth factor (PD-ECGF) and vascular endothelial growth factor (VEGF) in the serum of patients with acute cerebral infarction (ACI). Methods Thirty four patients with acute cerebral infarction and 30 healthy subjects (control group)were enrol ed in the study. The PD-ECGF and VEGF levels were detected by ELISA in patients on d1, d3, d7 and d14 after infarction as wel as in healthy controls. According to the size of lesions the patients were classified as large lesion group (n=10), middle lesion group (n=13) and smal lesion group (n=11); according to the etiology patients were classified as large-artery atherosclerosis group (LAA, n=15), smal -artery occlu-sion (SAO, n=10) group and cardioembolism (CE, n=9) group. Then the correlation between serum PD-ECGF,VEGF levels and infarct size, etiology were analyzed. Results Serum PD-ECGF and VEGF levels were significantly increased in patients with ACI at al time points compared with healthy controls (P<0.05). The levels of PD-ECGF in serum reached peak value after 3d, and VEGF reached peak value after 7d, and they remained high levels at d14 after stroke. PD-ECGF and VEGF showed dramatic in-crease in serum of large lesion group and LAA group (P<0.05). Conclusion The contents of serum PD-ECGF and VEGF in-crease dramatically in patients with acute cerebral infarction, and have correlation with infarct volume and etiology. The results in-dicate that PD-ECGF and VEGF may be involved in the pathophysiology of acute cerebral infarction.关键词
脑梗死/血小板衍生内皮细胞生长因子/血管内皮细胞生长因子/血管生成Key words
Cerebral infarction/Platelet derived endothelial cell growth factor/Vascular endothelial growth factor/Angiogenesis引用本文复制引用
张晓玲,钱淑霞,官俏兵,杜瑛媛,翟丽萍,王琰萍,俞晓翔..急性脑梗死患者血清 PD-ECGF和 VEGF 的动态变化[J].浙江医学,2013,(1):29-31,40,4.基金项目
浙江省中医药科学研究基金计划(20102B147) （20102B147）
