浙江医学Issue(2)：84-87,101,5.
血浆 miR-145在结直肠癌中的表达及临床意义
Expression of plasma miR-145 in colorectal cancer and its clinical significance
黄伟 1张乐鸣 2张怡 2陈莹2
作者信息
- 1. 315000 宁波大学医学院，硕士研究生
- 2. 宁波市第一医院肿瘤外科，重点实验室
- 折叠
摘要
Abstract
Objective To investigate the plasma expression of miR-145 in patients with colorectal cancer and its clinical significance. Methods The plasma levels of miR-145 in 53 patients with colorectal cancer and 26 healthy subjects were mea-sured using real-time quantitative PCR. The relationship between miR-145 expression and clinical characteristics of colorectal cancer was analyzed. The diagnostic value of miR-145 for colorectal cancer was evaluated. Results The plasma miR-145 lev-els were decreased significantly in colorectal cancer patients (P<0.01). The AUC (the area under the ROC curve) of miR-145 was 0.859 with a 86.8%sensitivity and 88.5%specificity in discriminating colorectal cancer from normal subjects; however, the expression levels of miR-145 were not associated with the gender, age, tumor location, nodal status, TNM staging, T-classifica-tion and CEA levels of patients (P >0.05). Conclusion A decreased plasma miR-145 levels are detected in patients with col-orectal cancer, which suggests miR-145 might be used as a potential tumor-marker for colorectal cancer.关键词
miRNA/miR-145/结直肠癌/血浆Key words
miRNA/miR-145/Colorectal cancer/Plasma引用本文复制引用
黄伟,张乐鸣,张怡,陈莹..血浆 miR-145在结直肠癌中的表达及临床意义[J].浙江医学,2013,(2):84-87,101,5.
