浙江医学Issue(2)：105-107,110,4.
G-HAA 方案治疗难治、复发性急性髓系白血病的疗效观察
Efficacy and safety of G-HAA regimen in treatment of refractory and relapsing acute myeloid leukemia
李双月 1曹俊杰 1庄贤栩 1吴静怡 1范峥 1林丽 1叶佩佩 1唐善浩 1张碧波 1史晓薇 1裴仁治 1张丕胜 1刘旭辉 1马俊霞 1杜小红 1陈冬 1沙科娅 1陈列光1
作者信息
摘要
Abstract
Objective To evaluate the efficacy and safety of G-HAA regimen consisting of low dose cytosine arabinoside (Ara-C), aclacinomycin (ACR), homoharringtonine (HHT) and granulocyte colony stimulating factor (G-CSF) in treatment of re-fractory and relapsing acute myeloid leukemia (AML). Methods Forty eight patients with refractory and relapsing AML, admitted from March 2008 to February 2012, were randomly assigned to CAG regimen (Ara-C, aclarubicin with G-CSF) and G-HAA regi-men. The two groups were further divided into three subgroups: children group (≤14y), young and middle-aged group (15 to 59y) and elderly group (≥60y) . The efficacy and side effects were analyzed and compared between the groups. Results The total complete remission (CR) rates in CAG group and G-HAA group were 69.6% and 76.0%, respectively (P >0.05) ; the overal effective rates (CR+PR) were 87.0% and 92.0%, respectively (P >0.05). The CR rates for M4、M5 subtype were 44.4% and 90.9%, in two groups respectively (P<0.05); but there was no difference in CR rates for M1、M2 subtype and MDS transformation. In chil-dren group, the CR rate treated with CAG regimen and G-HAA regimen were 37.5% and 90.0% respectively (P<0.05) , but there were no differences in the other two age groups. Further analysis of the children's group demonstrated that the CR rates for M4、M5 subtype of CAG regimen and G-HAA regimen were 20.0% and 100.0% respectively (P<0.05); but there were no differences in M1、M2 subtype. There were no significant differences in side effects among the groups. Conclusion The results indicate that the G-HAA regimen has the same efficacy and safety as CAG regimen in treatment of refractory and relapsing AML, however G-HAA regimen might be more effective in M4、M5 subtype, particularly in child patients.关键词
G-HAA方案/难治性/复发性/急性髓系白血病Key words
G-HAA regimen/Refractory/Relapse/Acute myeloid leukemia引用本文复制引用
李双月,曹俊杰,庄贤栩,吴静怡,范峥,林丽,叶佩佩,唐善浩,张碧波,史晓薇,裴仁治,张丕胜,刘旭辉,马俊霞,杜小红,陈冬,沙科娅,陈列光..G-HAA 方案治疗难治、复发性急性髓系白血病的疗效观察[J].浙江医学,2013,(2):105-107,110,4.
