浙江医学Issue(3)：167-170,174,5.
浙南地区女性人群CYP2D6及MDR1基因多态性对曲马多镇痛效果的影响
马光泛 1陈千煌1
作者信息
- 1. 325000 温州市中西医结合医院麻醉科
- 折叠
摘要
Abstract
Objective To investigate the association of CYP2D6*10 and MDR1 C3435T polymorphisms with analgesic ef-ficacy of tramadol in woman patients of Southern Zhejiang province. Methods One hundred and ninety four patients with hys-termyoma undergoing uterine myomatectomy from August 2010 to March 2012. Patients were given with loading dose of tramadol intramuscularly 30 minutes before the ending of surgery and received the postoperative patient-control ed analgesia (PCA). Samples of peripheral blood were col ected for DNA isolation. Polymorphisms of CYP2D6*10 and MDR1 C3435T were detected with PCR-RFLP analysis. The differences of tramadol consumption in the genotype groups were monitored and the starting time and duration of analgesia, VAS scores and adverse reaction were observed. Results The al elic frequency of CYP2D6 was 52.84%. The tramadol consumption at 2、6h and 12h after surgery and VAS at 2h and 6h after surgery in m/m type (n=50) were higher than those in w/w (n=39) and m/w (n=105) type (P<0.05). Variant al eles C3435T in MDR1 gene was seen in frequency of 38.14%. There were no significant differences in postoperative tramadol consumption and VAS among CC type (n=77), CT type (n=86) and TT type (n=31). Conclusion CYP2D6*10 is significantly associated with analgesic efficacy of tramadol in woman pa-tients of Southern Zhejiang province, while C3435T in MDR1 has no such association.关键词
MDR1 C3435T/CYP2D6*10/术后镇痛/基因多态性/曲马多Key words
MDR1 C3435T/CYP2D6*10/Postoperative analgesia/Polymorphisms/Tramadol引用本文复制引用
马光泛,陈千煌..浙南地区女性人群CYP2D6及MDR1基因多态性对曲马多镇痛效果的影响[J].浙江医学,2013,(3):167-170,174,5.
