浙江医学Issue(4)：268-270,276,4.
脑胶质瘤中脂肪酸酰胺水解酶的表达及意义
Expression of fatty acid amide hydrolase in brain glioma and its significance
摘要
Abstract
Objective To investigate the expression of endocannabinoid metabolic enzyme fatty acid amide hydrolase (FAAH)in human brain glioma tissues and its clinicopathological significance. Methods Twenty-three patients with brain glioma, including one case with grade I, 7 grade II, 5 grade III,2 grade III~IV and 8 glioblastoma, undergoing surgical excision were enrol ed in the study; and 8 samples of normal brain tissues from patients undergoing decompression operation due to cerebral hernia served as controls. qRT-PCR and HPLC-MS were used to detect the mRNA and the activity of FAAH, respec-tively. Results The expression of mRNA and activity of FAAH was significantly higher in low grade (gradeⅠ~Ⅱ) and high grade (gradeⅢ~Ⅳ) brain glioma than those in the normal brain tissues (P<0.01). The expression of FAAH mRNA was positively corre-lated with the FAAH Activity,and both were negatively correlated with the pathological grades (P<0.01). Conclusion FAAH may be involved in the occurrence and development of brain glioma;the detection of FAAH expression may be of value in evaluation of biological behavior and prognosis of brain glioma.关键词
大麻素/花生四烯酸乙醇胺/FAAH/胶质瘤Key words
Cannabinoid/Anandamide/FAAH/Glioma引用本文复制引用
张小林,蒋峰,龚清永,韩丽君,任杰,林志雄,傅瑾..脑胶质瘤中脂肪酸酰胺水解酶的表达及意义[J].浙江医学,2013,(4):268-270,276,4.基金项目
卫生部科学研究基金-福建省卫生教育联合攻关计划资助项目(WKJ2008-2-45) （WKJ2008-2-45）
