浙江医学Issue(6)：418-420,440,4.
SAH后下丘脑中5-羟色胺、去甲肾上腺素水平改变及地塞米松的作用
Levels of 5-hydroxytryptamine and noradrenaline in rat hypothalamus after subarachnoid hemorrhage and effects of dexamethasone
摘要
Abstract
Objective To investigate the levels of 5-hydroxytryptamine (5-HT) and norepinephrine (NA) in rat hypothala-mus after subarachnoid hemorrhage (SAH), and the effect of dexamethasone (DXM) on 5-HT and NA. Methods The rats were randomly divided into 4 groups:the blank, SAH control, SAH treated by intracisternal DXM and SAH treated with intraperitoneal DXM. The levels of 5-HT and NA were measured by high performance liquid chromatograph. Results The 5-HT in hypothala-mus tissue began to rise in 3d, reached to peak in 7d, remained at high level in 14d and went down to d3 level in 21d, which was consistent with the timing of delayed cerebral ischemic. The NA in hypothalamus tissue began to rise in 3d and kept rising in 7, 14 and 21d, which was not consistent with the mode of 5-HT. The levels of 5-HT were decreased after DXM treatment and there was no significant difference between intracisternal and intraperitoneal administration. There were no changes of NA levels after DXM treatment. Conclusion 5-HT and NA levels in hypothalamus are increased after SAH, which may be involved in abnormal-ity of sleep/wakefulness, but the time modes of 5-HT and NA are different. DXM may promote wakefulness by lowering 5-HT level in hypothalamus after SAH, and DXM can be administrated intracisternal y as an alternative way.关键词
蛛网膜下腔出血/5-羟色胺/去甲肾上腺素/地塞米松Key words
Suharachnold hemorrhage/5-hydroxytryptamine/Noradrenaline/Dexamethasone引用本文复制引用
刘艳,熊丹,张小洁,钱聪,信照亮..SAH后下丘脑中5-羟色胺、去甲肾上腺素水平改变及地塞米松的作用[J].浙江医学,2013,(6):418-420,440,4.基金项目
国家自然科学基金项目(30370497) （30370497）
浙江省社会发展项目(2007C33039) （2007C33039）
