摘要
Abstract
Objective To evaluate the efficacy and safety of combination of memantine and donepezil in treatment of pa-tients with Alzheimer disease (AD). Methods Eighty patients with AD were randomly assigned to receive combination of me-mantine (starting dose 5 mg/d, 5 mg weekly increments,20 mg/d after 4 weeks) and donepezil (starting dose 5 mg/d, 10 mg/d after 4 weeks) (combination group, n=40) or donepezil alone (control group, n=40) for 12 weeks. The behavioral and psychologi-cal symptoms, activities of daily living and clinical global impression were evaluated with Behavioral Pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD), Activities of Daily Living Inventory (ADL) and Clinical Global Impression Scale (CGI) before and after treatment. Results At the end of week 12, the scores of BEHAVE-AD and ADL were lower in combination treatment group than those in control group (8.1±3.30 vs 9.2±2.80, t=-3.317, P=0.002) and (28.1±2.35 vs 29.3±2.63, t=2.097, P<0.05), respectively. The CGI score in combination group was better than that in control group (3.43±0.82 vs 4.37±0.85, t=-5.413, P<0.01). Six patients (15.0%) in combination group and 5 patients (12.5%) in control group developed mild adverse effects respec-tively. Conclusion Combination of memantine and donepezil achieves better efficacy than donepezil alone in treatment of pa-tients with Alzheimer disease.关键词
阿尔茨海默病/精神和行为症状/盐酸多奈哌齐/盐酸美金刚Key words
Alzheimer Disease/Behavioral and psychological symptoms/Donepezil/Memantine
