摘要
Abstract
Objective To investigate the application of serum and pleural fluid procalcitonin(S-PCT and PF-PCT) levels in evaluation of patients with parapneumonic pleural effusion (PPPE). Methods Eighty patients with PPPE were included in the study, including 42 cases of uncomplicated pleural effusion (UCPE) and 38 cases of complicated pleural effusion (CPE);30 pa-tients with transudate patients served as controls. The PH, glucose and lactate dehydrogenase (LHD) levels in pleural fluid or in trasnudate as wel as S-PCT and PF-PCT were measured in three groups. Results There were significantly difference in PH, glucose and LDH among three groups (P<0.05).The levels of S-PCT and PF-PCT were higher in PPPE patients than those in controls(P<0.01). There were no significantly difference in S-PCT levels between UCPE and CPE groups(P>0.05),but the differ-ence in PF-PCT levels was significant (P<0.05). The S-PCT level was positively correlated with PF-PCT level in three groups(r=0.70, P<0.05). Both S-PCT and PF-PCT levels significantly increased in high risk patients classified by the PSI score (P<0.05), whose hospital stay>3 weeks, or in whom complications or death occurred (P<0.05). PF-PCT/S-PCT levels were significantly decreased in patients who had pleural thickening or need surgical procedures (P<0.05). The cut-off value of PF-PCT >0.25ng/mL was used for diagnosis of CPE with a sensitivity of 80%and specificity of 76%. Conclusion The levels of S-PCT and PF-PCT can be used in clinical evaluation of patients with PPPE;PF-PCT may differentiate UCPE from CPE, which need thoracic closing drainage, thoracic injection of fibrinolytic agents or possible thoracoscopic surgery for treatment.关键词
血清降钙素原/胸腔积液降钙素原/胸腔积液降钙素原/血清降钙素原/肺炎旁胸腔积液/单纯性肺炎旁胸腔积液/复杂性肺炎旁胸腔积液Key words
S-PCT/PF-PCT/PF-PCT/S-PCT/PPPE/UCPE/CPE
