摘要
Abstract
Objective To investigate the effect of atorvastatin on the expression of transforming growth factor-β1 (TGF-β1) and col agen in rat model of chronic obstructive pulmonary disease (COPD). Methods Male SD rats were divided in-to three groups; control group, COPD model group and atorvastatin intervention group. After 10 weeks,airway resistance (RL) and dynamic compliance (Cdyn) was measured;the pathological features of lung tissue of three groups were observed;the ex-pressions of TGF-β1 and col agen content in bronchial and lung tissue were measured. Results In COPD model the peripheral bronchiolar smooth muscle layer and collagen in extracel ular matrix increased significantly compared to the healthy control group. In intervention group RL reduced (P<0.01) and Cdyn increased (P<0.01) compared to model group. The expressions of TGF-β1 of COPD model group was 5.66±0.35/μg·L-1, which was significantly higher than that in intervention group (3.25± 0.69/μg·L-1, P<0.01) and healthy control group (1.62±0.46/μg·L-1, P<0.01). The expression of col agen of bronchial and pul-monary tissue in COPD group was (17.18 ± 5.34)%, which was higher than that in healthy group (7.42±2.97%, P<0.01), the expression of col agen of intervention group was (11.94 ± 4.03)%, which was higher than that in healthy group(P<0.05) and low-er than that in COPD group (P<0.01). The expression of TGF-β1 was positively correlated with collagen expression in bronchial and pulmonary tissue (r=0.802, P<0.01). Conclusion The increased col agen deposition in bronchial and pulmonary tissue is an important pathological changes of COPD airway remodeling, which is associated with up-regulation of TGF-β1 expression. Early administration of atorvastatin can significantly inhibit TGF-β1 expression and interfere in the development of COPD rat air-way remodeling.关键词
慢性阻塞性肺疾病/转化生长因子-β1/胶原/阿托伐他汀Key words
Chronic obstructive pulmonary disease/Transforming growth factor-β1/Collagen/Atorvastatin
