浙江医学Issue(10)：889-891,894,4.
不同手术时间对骨折愈合过程中VEGF表达的影响
Time interval of operation on VEGF expression in bone during fracture healing
摘要
Abstract
Objective To observe the effect of time interval of operation on the expression of vascular endothelial growth factor (VEGF) in bone during fracture healing in rats. Methods Closed femoral fracture was induced in 192 Wistar rats. The frac-ture was treated with open reduction and internal fixation operation at 1, 3, 5, 7, 11 and 14d after fracture. The expression of VEGF in fracture end at different time points (d1, 3, 5, 7, 11, 14, 21, 35 and 49) were detected with immunohistochemical staining. Re-sults The expression of VEGF was strongest and last longer in rats operated at d7 or d11 after fracture, fol owed by those oper-ated at d14. The expression intensity was higher in rats operated d5 after fracture than those without operation. There was no dif-ference in VEGF expression between rats operated at d1 and non-operated rats;while rats operated at d3 presented low VEGF expression at al time points of fracture healing,which even lower than that in rats without operation. Conclusion The results sug-gest that the optimal timing of surgery may be within the 1~2 weeks after fracture.关键词
骨折愈合/血管内皮细胞生长因子/手术时间Key words
Fracture healing/Vascular endothelial growth factor/Operative time引用本文复制引用
董黎强,尹航,王维佳,王昌兴,胡伟锋..不同手术时间对骨折愈合过程中VEGF表达的影响[J].浙江医学,2013,(10):889-891,894,4.基金项目
浙江省教育厅科研项目 （）
