浙江医学Issue(11)：1049-1051,3.
MicroRNA-143对人乳腺癌MCF-7细胞侵袭和迁移的影响
摘要
Abstract
Objective To investigate the effect of microRNA-143 (miR-143) on invasion, migration and proliferation po-tential of human breast cancer MCF-7 cel s. Methods MCF-7 cells were transfected with miR-143 inhibitors by lipofectamine. MCF-7 cel s transfected with inhibitor negative control were used as negative control(inhibitor NC). Cel proliferation potential was evaluated by MTS kit, cel invasion potential and migrating ability were detected by transwel invasion and migration assay. Re-sults There were no significantly differences in cel growth between cel s transfected with miR-143 inhibitors and inhibitor NC cel s(P>0.05). Transfection of miR-143 inhibitors into MCF-7 cel s led to a significant increase in cel invasion and migration de-tected by transwel invasion and migration assay(P<0.05). Conclusion MiR-143 negatively regulates the invasion and migration potential of human breast cancer MCF-7 cel s and may be a potential target for breast cancer treatment.关键词
miR-143/Transwel/侵袭/迁移/增殖Key words
MiR-143/Transwel/Invasion/Migration/Proliferation引用本文复制引用
李斐铭,葛晓英,王超群,黄必飞..MicroRNA-143对人乳腺癌MCF-7细胞侵袭和迁移的影响[J].浙江医学,2013,(11):1049-1051,3.基金项目
浙江省医药卫生科技计划项目 （）
