浙江医学Issue(12)：1114-1116,3.
多形性脑胶质母细胞瘤中1p/19q杂合性缺失的表达及其意义
摘要
Abstract
Objective To investigate the loss of heterozygosity of 1p and/or 19q chromosomal arms (1p/19q LOH) in glioblastoma multiforme (GBM) and its significance. Methods The 1p/19qLOH patterns in 29 cases of GBM, 17 cases of anaplastic astrocytoma (AA) and 12 cases of oligodendroglioma (OA) were examined by using fluorescence in situ hybridization (FISH) method. Results 1p/19q whole loss was observed in 13.8% of GBM cases, 23.5%of AA and 66.7%of OA. The rate of 1pLOH or 19qLOH in GBM, AA and OA cases was 24.1%, 35.3%and 75.0%respectively. The 1p/19qLOH rate in GBM was sig-nificantly lower than that in AA and OA (P<0.05). The positive expression of VEGF and Ki-67 proliferating index (Ki-67 PI) were 75.9%and 87.66±16.21 in GBM, 47.1%and 49.57±4.73 in AA and 41.7%and 41.62±4.25 in OA respectively. The positive ex-pression of VEGF and Ki-67 PI in GBM was significantly higher than that in AA and OA groups (P<0.05). The 1p/19qLOH was negatively correlated with expression of VEGF, and Ki-67 PI (P<0.05). Conclusion The 1p/19qLOH may be an useful genetic marker to estimate chemotherapeutic sensitivity and prognosis of GBM.关键词
多形性胶质母细胞瘤/1p/19q杂合性缺失/化疗/预后Key words
GBM 1p/19qLOH/Chemotherapy/Prognosis引用本文复制引用
楼林,方晴霞,郑小春,茹国庆,马杰,卢刚..多形性脑胶质母细胞瘤中1p/19q杂合性缺失的表达及其意义[J].浙江医学,2013,(12):1114-1116,3.基金项目
浙江省卫生厅医药卫生科技计划项目 （）
