浙江医学Issue(12)：1136-1137,1167,3.
初诊急性髓系白血病患者FLT3-ITD和NPM1基因联合突变与临床特征的关系
陈岳华 1陶师 1朱卫国 1王云贵 2钱文斌2
作者信息
- 1. 312000 绍兴第二医院血液科
- 2. 浙江大学医学院附属第一医院血液科
- 折叠
摘要
Abstract
Objective To investigate the frequency of Fms-like tyrosine kinase 3 tandem duplication (FLT3-ITD) and nu-cleophosmin 1 (NPM1) gene mutations in patients with incipient acute myeloid leukemia (AML), and its relationship with clinical features of patients. Methods Bone marrow samples were col ected from 44 AML cases, the FLT3-ITD and NPM1 gene muta-tions were examined by genomic DNA PCR, and the relationship between gene mutations and clinical features was analyzed. Results FLT3-ITD gene mutations were detected in 10 cases with a detection rate of 22.7%. The median WBC count in AML pa-tients with FLT3-ITD mutation was (98.5±22.5)×109/L, and that in those with no FLT3-ITD mutation was (42.9±12.4)×109/L(P<0.05). NPM1 gene mutations were detected in 14 cases with a detection rate of 31.8%. Most patients with mutations had normal karyotype. Conclusion FLT3-ITD and NPM1 gene mutations are frequent abnormalities in acute myeloid leukemia, which may affect the prognosis of patients.关键词
白血病/FLT3-ITD/NPM1/基因突变Key words
Leukemia/FLT3-ITD/NPM1/Gene mutation引用本文复制引用
陈岳华,陶师,朱卫国,王云贵,钱文斌..初诊急性髓系白血病患者FLT3-ITD和NPM1基因联合突变与临床特征的关系[J].浙江医学,2013,(12):1136-1137,1167,3.
