浙江医学Issue(12)：1150-1152,3.
血清瘦素水平在评估慢性病毒性肝炎肝纤维化程度中的意义
摘要
Abstract
Objective To evaluate the relationship between serum leptin (LEP) levels and the severity of fibrosis in chronic hepatitis B (CHB) and chronic hepatitis C (CHC) patients. Methods Serum samples were collected from 65 patients with CHB, 41 patients with CHC and 25 healthy subjects (controls). The serum LEP levels were determined with enzyme-linked immunosor-bent assay, and the liver fibrosis was assessed by liver biopsy in al patients. Results Compared to healthy controls, serum LEP levels in CHB and CHC patients were significantly higher. The serum LEP levels in CHB and CHC patients with higher fibrosis stage were significantly higher than those with lower fibrosis stage (P<0.01). Meanwhile, the serum LEP levels were significantly higher in CHC patients than those in CHB patients at the same stage of hepatic fibrosis. Conclusion High serum LEP level is closely associated with liver fibrosis in CHB and CHC patients, which indicates that serum LEP level can be used as early indica-tor for disease progression in patients with chronic viral hepatitis.关键词
瘦素/慢性乙型肝炎/慢性丙型肝炎/肝纤维化Key words
Leptin/Chronic hepatitis B/Chronic hepatitis C/Fibrosis引用本文复制引用
卢莺燕,王伟,周林福,陶晓东..血清瘦素水平在评估慢性病毒性肝炎肝纤维化程度中的意义[J].浙江医学,2013,(12):1150-1152,3.基金项目
浙江省医药卫生科学研究计划项目 （）
