浙江医学Issue(13)：1257-1259,3.
Tregs细胞CCR4、CCR6表达异常在类风湿关节炎患者发病时的意义
The pathogenic significance of increased CCR4,CCR6 expression on Tregs cells in rheumatoid arthritis
摘要
Abstract
Objective To explore the role of CCR4 andCCR6 abnormal expression on Tregs in RA and the mechanism that may be involved. Methods Peripheral blood mononuclear cel s (PBMC) were isolated from blood in RA patients. Im-munofluorescence staining and flow cytometry assay were used to detect the expression of CCR4, CCR6 on Tregs surface. The correlation analysis between expression level of CCR4 and CCR6 on Tregs and the clinical activity parameters was performed. Results The expression of Tregs in peripheral blood of RA patients was lower than healthy control(P<0.05). The expression levels of chemokine receptor of CCR4, CCR6 on Tregs cell in peripheral blood of RA patients in active phase were higher than healthy control(P<0.05).The expression levels of chemokine receptor CCR4, CCR6 on Tregs cel in RA patients who were in active phase was positively correlated with the level of the DAS28 score (P<0.05).Conclusion The increased expression of CCR4, CCR6 on Tregs surface in rheumatoid arthritis patients not only means Tregs cell obtain the capability to directional migrate to joint, but also represents feedback regulation in the body's inflammatory response.关键词
Tregs细胞/CCR4/CCR6/类风湿关节炎Key words
Tregs/CCR4/CCR6/Rheumatoid Arthritis引用本文复制引用
魏巍,刘葵葵,韩捷..Tregs细胞CCR4、CCR6表达异常在类风湿关节炎患者发病时的意义[J].浙江医学,2013,(13):1257-1259,3.基金项目
余姚市科技计划项目 （）
