肿瘤药学Issue(1)：35-38,4.DOI:10.3969/j.issn.2095-1264.2013.008
舒芬太尼静脉自控镇痛对肺癌术后患者疼痛和血清IL-6及IL-10的影响
Effects of the Controlled Intravenous Analgesia by Sufentanil on Plasma IL-6 and IL-10 levels on Patients after Lung Cancer Surgery
摘要
Abstract
Objective To evaluate the effects of the controlled intravenous analgesia by sufentanil on plasma IL-6 and IL-10 levels on patients who suffered lung cancer operation. Methods Sixty lung cancer surgery patients (ASAⅠ-Ⅱgrade) were selected and divided randomly into three groups (n=20):Saline control group (group C), Fentanyl group (group F) and sufentanil group (group S). The visual analog scale (VAS) and serum concentrations of IL-6 and IL-10 were measured and compared between the three groups. Results Compared with group C, VAS scores and the levels of IL-6 and IL-10 on av-erage significantly decreased in group F and group S (P<0.05). Compared with group F, the serum levels of IL-6 and IL-10 and VAS significantly decreased in group S (P<0.05). Conclusion Controlled intravenous analgesia by Sufentanil is more effective than Fentanil in the treatment of patients after lung cancer operation. It could effectively maintain the balance of cy-tokines and relieve the immunologic injury post operation.关键词
肺癌手术/舒芬太尼/疼痛/自控静脉镇痛/白介素6/白介素10Key words
Lung cancer surgery/Sufentanil/Pain/Patient-controlled intravenous analgesia/IL-6/IL-10分类
医药卫生引用本文复制引用
冯涛,郭曲练,刘景诗,王懿春,唐顺山..舒芬太尼静脉自控镇痛对肺癌术后患者疼痛和血清IL-6及IL-10的影响[J].肿瘤药学,2013,(1):35-38,4.基金项目
湖南省科技厅重点项目资助(2012FJ2004) （2012FJ2004）
