肿瘤药学Issue(1)：64-69,74,7.DOI:10.3969/j.issn.2095-1264.2013.015
高危乳腺癌辅助化疗后白细胞减少的危险因素及其与预后的相关性研究
Analysis on Risk Factors of Adjuvant Chemotherapy-induced Leucopenia in High Risk Breast Cancer and its Relationship with the Prognosis
陈焕伟 1王博 1凌华海 1林坚1
作者信息
- 1. 广东省农垦中心医院，湛江肿瘤医院，广东 湛江，524002
- 折叠
摘要
Abstract
Objective To examine the relationship between the adjuvant chemotherapy-induced leucopenia (CIL) and curative effects in high risk breast cancer patients. Methods 106 patients were treated with FAC-D regimen. According to the degree of CIL, the patients were classified into three groups:no reduction of leucopenia as control group;Ⅰ~Ⅱleucopenia as the observation group 1;Ⅲ~Ⅳleucopenia as the observation group 2. The disease-free survival (DFS) and overall survival (OS) in three groups were compared and the relationship between CIL risk factors and chemotherapy curative effects were analyzed. Results CIL in observation group 1 and observation group 2 was 51.0%and 26.5%respectively. The disease-free survival rate was 56.5%, 78.8%and 67.9%respectively for the control group, observation group 1 and observation group 2. The overall survival rate was 70.8%, 88.9%and 82.1%respectively in the control group, observation group 1 and observa-tion group 2. Compared with the other two groups, DFS and OS were obviously higher in observation group 1 (P<0.05). It was positively correlated between the degree of CIL and the DFS and OS (P<0.05). It was showed that the number and size of transfer lymph node, foundation of white blood cells, gastrointestinal reaction were the risk factors of chemotherapy related leucopenia in breast cancer;while the age, wound healing, ER state had nothing to do with it. Conclusion The risk factors of chemotherapy induced leucopenia in breast cancer include the number and size of transfer lymph node, foundation of white blood cells, gastrointestinal reaction. Chemotherapy-related leucopenia may be taken as an indicator for prognosis of patients with breast cancer after chemotherapy.关键词
化疗相关性白细胞减少/乳腺癌/辅助化疗/预后/危险因素Key words
Chemotherapy-induced leucopenia/Breast cancer/Adjuvant therapy/Prognosis/Risk factor分类
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陈焕伟,王博,凌华海,林坚..高危乳腺癌辅助化疗后白细胞减少的危险因素及其与预后的相关性研究[J].肿瘤药学,2013,(1):64-69,74,7.
