肿瘤药学Issue(2)：82-86,95,6.DOI:10.3969/j.issn.2095-1264.2013.019
新型血管生成抑制剂 Borrelidin 抗肿瘤作用及其合成的研究进展★
Research Progress on the Anti-tumor Activities and Synthesis of the Potent Angiogenesis Inhibitors Borrelidin★
摘要
Abstract
Borrelidin, isolated from Streptomyces rochei, is a C18 macrolide compound, with several interesting and potent biological activities including antibacterial, antimalarial and antiviral activity. It has been reported in recent years that Borrelidin also has tumor growth inhibitory activity (IC50=0.8 nM) which may be attributed to inhibition of angiogenesis, and becomes a potential angiogenesis inhibitor. Angiogenesis research has become one of the most attractive, exciting and promising areas in cancer research and treatment. The structural novelty and vital biological activities and its derivates have attracted a great amount of research devoted to the structural optimization in order to discover more potent compounds with fewer side ef-fects. Herein, we reviewed its anti-tumor activities, mechanisms, as well as its synthesis, concentrating on recent case histories in oncology drug discovery.关键词
Borrelidin/ThrRS/血管生成抑制Key words
Borrelidin/ThrRS/Inhibition of angiogenesis分类
医药卫生引用本文复制引用
周明,胡亮,余聂芳..新型血管生成抑制剂 Borrelidin 抗肿瘤作用及其合成的研究进展★[J].肿瘤药学,2013,(2):82-86,95,6.基金项目
国家自然科学基金项目资助(81172927) （81172927）
