肿瘤药学Issue(2)：111-114,4.DOI:10.3969/j.issn.2095-1264.2013.026
自体造血干细胞移植治疗复发弥漫大B细胞淋巴瘤的疗效观察
Therapeutic Effect of Autologous Stem Cell Transplantation in the Adjuvant Treatment of Recurrence Diffuse Large B-cell Lymphoma
孙中义 1易平勇 1刘晰宇 1周芳 1欧阳周 1贺军侨 1黄利军 1姚远1
作者信息
- 1. 湖南省肿瘤医院淋巴瘤血液内科，湖南 长沙，410013
- 折叠
摘要
Abstract
Objective To approach the therapeutic effect and reliability of high dose therapy supported by autologous stem cell transplantation for recurrence diffuse large B-cell lymphoma. Methods 72 patients with recurrence diffuse large B-cell lym-phoma who hospitalized in our department during January 2000 and December 2011 were divided randomly into transplantation group and routine-chemotherapy group according to the ways of therapy and each group included 36 patients. Patients in trans-plantation group were administrated with ICE schedule for 4-6 periods before autologous peripheral blood stem cell transplan-tation, and received radiotherapy if they didn’t get complete remission after transplantation. Patients in routine-chemotherapy group were only administrated with ICE schedule for 4-6 periods, and were offered with radiotherapy if no complete remission. Therapeutic effect and adverse reaction was observed and compared after treatment. Results In transplantation group, there were 33 cases (91.7%) of complete remission, and 3 cases (8.3%) of partial remission. While in the routine-chemotherapy group, there were 23 cases (63.9%) of complete remission, and 13 cases (36.1%) of partial remission. There was significant statistical difference in curative effect between the two groups (P<0.05). The incidence of Ⅳ degree bone marrow depression in transplantation group was apparently higher than that of routine-chemotherapy group (P<0.05), but no statistical difference was found in incidence of gastrointestinal tract reaction between two groups. 5-year OS was respectively 56% and 38% in transplantation group and rou-tine-chemotherapy group, and 5-year DFS was respectively 43% and 20% , both with statistically significant difference (P<0.05).Conclusion The therapeutic effect of high dose therapy supported by autologous stem cell transplantation for recurrence dif-fuse large B-cell lymphoma was much better than that of routine-chemotherapy, and adverse reaction was tolerant.关键词
弥漫大B细胞淋巴瘤/自体造血干细胞移植/化疗Key words
Diffuse large B-cell lymphoma/Autologous stem cell transplantation/Chemotherapy分类
医药卫生引用本文复制引用
孙中义,易平勇,刘晰宇,周芳,欧阳周,贺军侨,黄利军,姚远..自体造血干细胞移植治疗复发弥漫大B细胞淋巴瘤的疗效观察[J].肿瘤药学,2013,(2):111-114,4.
