肿瘤药学Issue(2)：122-125,4.DOI:10.3969/j.issn.2095-1264.2013.029
替莫唑胺联合放疗治疗脑转移瘤的临床研究
A Clinical Study on Temozolomide Combined with Radiotherapy in Treating Metastatic Brain Tumors
肖勇辉 1郑志坚 2曾黄辉1
作者信息
- 1. 梅州市人民医院药剂科，广东 梅州，514031
- 2. 梅州市人民医院放疗科，广东 梅州，514031
- 折叠
摘要
Abstract
Objective To study the clinical efficacy and adverse reactions of temozolomide combined with radiotherapy for brain metastases. Methods 44 patients with brain metastases were selected and divided equally into treatment group and control group, 22 cases in each group. The treatment group received temozolomide combined with radiotherapy while the control group was treated with radiotherapy alone. The tumor regression, survival time and changes of KPS were observed and analyzed. The clinical efficacy and toxicity occurrence were evaluated after treatments. Results All patients were success-fully completed the treatment program. The treatment group had a total effective rate of 68.18% and the control group had a total effective rate of 36.36%; there was a significant difference between the two groups (P<0.05). There was no significant difference in toxicity occurrence between the treatment group and the control group (P>0.05). Conclusion Temozolomide combined with radiotherapy had a better effect and less toxicity than simple whole-brain radiation therapy on brain metastases, therefore, it is worth being generalized and applied in clinic.关键词
替莫唑胺/脑转移瘤/放疗Key words
Temozolomide/Brain metastases/Radiotherapy分类
医药卫生引用本文复制引用
肖勇辉,郑志坚,曾黄辉..替莫唑胺联合放疗治疗脑转移瘤的临床研究[J].肿瘤药学,2013,(2):122-125,4.
