肿瘤药学Issue(3)：180-184,5.DOI:10.3969/j.issn.2095-1264.2013.043
MMP-9和E-cadherin在乳腺癌中的表达及其临床意义
Expression and Clinical Significance of MMP-9 and E-cadherin in Breast Cancer
刘力 1谭米多 1戴洪波 1王文婷 1谢海辉 1刘国文1
作者信息
- 1. 南华大学第二附属医院，湖南 衡阳，421001
- 折叠
摘要
Abstract
Objective To study the expression and clinical significance of MMP-9 and E-cadherin in breast cancer. Methods 20 cases of normal breast tissue from patients with fiberoadenoma, 20 cases of mammary hyperplasia tissues and 50 cases of breast invasive ductal carcinoma tissues were selected. The expressions of MMP-9 and E-cadherin were detected by immunohisto-chemistry, and the correlation of their expressions with the clinicpathological characteristics of patients with breast cancer was analyzed. Results The positive rate of MMP-9 expression in normal breast, breast hyperplasia and breast cancer tissues was re-spectively 5%, 30%, 66%, which was significantly higher in the breast cancer than in other tissues (P<0.05). Whereas the posi-tive rate of E-cadherin expression in the three groups was respectively 95%, 85%, 42%, which was significantly lower in the breast cancer than that in other tissues (P<0.05). There was a significant negative correlation between the expression of MMP-9 and E-cadherin (r=0.605, P<0.05). Both the expressions of MMP-9 and E-cadherin protein were significantly correlated with the histological grade, tumorous TNM staging and axillary lymph node metastasis of breast cancer (P<0.05), but not related to the age and tumor size (P>0.05). Conclusion Both MMP-9 and E-cadherin played important roles in the development of breast cancer, and their expressions were negatively correlated with each other in breast cancer. Therefore, the combination detection of the two could contribute to the prognosis evaluation of breast cancer.关键词
乳腺癌/基质金属蛋白酶-9/E-钙粘蛋白/上皮间质转化Key words
Breast cancer/MMP-9/E-cadherin/Epithelial-mesenehymal transition分类
医药卫生引用本文复制引用
刘力,谭米多,戴洪波,王文婷,谢海辉,刘国文..MMP-9和E-cadherin在乳腺癌中的表达及其临床意义[J].肿瘤药学,2013,(3):180-184,5.
