中山大学学报（自然科学版）Issue(3)：77-82,6.
一株南海珊瑚细菌L-4抗肿瘤活性次生代谢产物研究
Anti-tumour Secondary Metabolites from the Coral-derived Bacteria L-4 of South China Sea
摘要
Abstract
The influence of secondary metabolites on the mix-cultivate marine bacteria and fungus were studied.The result indicated that bacteria obviously affected the secondary metabolites of fungus in the mix-cultivate, and even produce substances that were not found in the fungus or bacteria separately cul -ture by TLC.Eight compounds were obtained from the fermentation broth of coral-derived bacteria L-4 in South China Sea.Their structures were determined to be cyclo (Trp-Ala) (1), cyclo (Gly-Tyr) (2), cyclo (Ala-Tyr) (3), and cyclo (Val-Tyr) (4), cyclo (Gly-Phe) (5), cyclo (Gly-Pro) (6), cyclo (Ala-Val) (7), and cyclo (Gly-Ala) (8) by spectroscopic analysis.The compounds 1, 2, 3, 4, 5, 6, 7, 8 were all cyclo-dipeptides and first obtained from the marine coral-derived bacteri-um of South China Sea, which attributed to further research metabolism of mix-cultivation.关键词
珊瑚细菌/混合培养/次级代谢产物/环二肽/结构鉴定Key words
coral-derived bacteria/mix-cultivate/secondary metabolites/cyclo-dipeptides/structure i-dentification分类
化学化工引用本文复制引用
郭琼,王剑,姚俊华,雷玲芳,陈小洁,邓芸,黄兆胜,张翠仙..一株南海珊瑚细菌L-4抗肿瘤活性次生代谢产物研究[J].中山大学学报（自然科学版）,2013,(3):77-82,6.基金项目
国家自然科学基金资助项目（81001370）；中国科学院海洋生物资源可持续利用重点实验室联合基金资助项目（LMB101002）；广东省大学生创新实验资助项目 （）
