中国现代中药Issue(9)：917-921,5.DOI:10.13313/j.issn.1673-4890.2015.9.009
翻白草总黄酮及翻白草复方的降血糖作用研究
Studies on Hypoglycemic Effects of Total Flavonoids and Compound Prescription Containing Potentilla discolor Bge.
孙琛 1张健 1王征 1宋忠兴 2刘红波 2谢培 1唐志书1
作者信息
- 1. 陕西中医药大学/陕西省中药资源产业化协同创新中心，陕西 咸阳 712083
- 2. 陕西省中药基础与新药研究重点实验室，陕西 咸阳 712046
- 折叠
摘要
Abstract
Objective:To investigate the hypoglycemic effects of total flavonoids and compound prescription containing Potentilla discolor Bge.on hyperglycemia mice.Methods:Kunming micewere used as experiment animal,the model mice of alloxan-diabetes were randomly divided into these groups:control group,model group,metformin group,diabetes pill group, total flavonoids in high-dose group(320 mg·kg -1 ),total flavonoids in middle-dose group(160 mg·kg -1 ),total flavonoids in low-dose group (80 mg·kg -1 ),compound in high-dose group (10 g herbs·kg -1 ),compound in middle-dose group (5 g herbs·kg -1 ),compound in low-dose group(2.5 g herbs·kg -1 ).Body weight,blood sugar,the insulin sensitivity index, catalase,and glutathion peroxidase in serum were measured after 14 days.Results: Total flavonoids and the compoundprescription could reduce the blood glucose of hyperglycemia mice,and significantly improve the insulin sensitivity index,and the mice of catalase (CAT)activity as well as glutathione peroxidase (GSH-Px)activity.Conclusion:Total flavonoids and the compound prescription could significantly increase the antioxidant activity and reduce insulin resistance of mice.The hypoglycemic effects of compound was better thanthat of total flavonoids.关键词
翻白草总黄酮/复方/降血糖作用Key words
Flavonoids of Potentilla discolor Bge./compoundprescription/hypoglycemic effects引用本文复制引用
孙琛,张健,王征,宋忠兴,刘红波,谢培,唐志书..翻白草总黄酮及翻白草复方的降血糖作用研究[J].中国现代中药,2015,(9):917-921,5.
