中国现代中药Issue(9)：953-956,969,5.DOI:10.13313/j.issn.1673-4890.2015.9.016
星点设计-响应面法优化黄柏提取工艺研究
Optimization of Extraction Process of Cortex Phellodendri Chinensis by Central Composite Design-response Surface Methodology
摘要
Abstract
Objective:To optimize extraction process of Cortex Phellodendri Chinensis by central composite design-response surface methodology.Methods:Water was chose as the extraction solvent and the effect of three factors such as solvent-solid ratio,extraction time and times was designed by Box-Behnken central composite,taking the content of berberine hydrochloride as evaluation indicator.Extraction process was optimized by central composite design-response surface methodology.Results:The optimizing extraction process of Cortex Phellodendri Chinensis were as follows:ratio of liquid to solid was 8:1,extraction repeated 3 times,90 minutes every time.The yield of berberine hydrochloride under this condition was 32.15 mg·g -1.Conclusion:Optimizing extraction process of Cortex Phellodendri Chinensis by central composite design-response surface methodology is reasonable,simple,and has good predictability.关键词
星点设计-响应面法/黄柏/工艺优化Key words
Central composite design-response surface methodology/Cortex Phellodendri Chinensis/process optimization引用本文复制引用
武婧,宋忠兴,古川,刘红波,翟思程,唐志书..星点设计-响应面法优化黄柏提取工艺研究[J].中国现代中药,2015,(9):953-956,969,5.基金项目
国家自然科学基金资助项目（81373978）；陕西省重点科技创新团队资助项目 （）
