中医药学报Issue(5)：27-30,4.
丹皮酚对甲状腺未分化癌 FRO细胞相关 lncRNA表达的影响
Effect of Paeonol on the Expressive Level of IncRNA in Human Thyroid Cancer Cell Line FRO
摘要
Abstract
Objective:To investigate whether the traditional Chinese medicine Paeonol can affect the expressive level of lncRNA in human thyroid cancer cell line FRO .Methods:Human thyroid cancer cell line FRO was incubated with dif-ferent concentrations of paeonol for 48 h.Then cell survival rate was measured by MTT assay and cell morphology change was observed by phase contrast microscope .The expressive level of cancer -related lncRNA (H19,HOT,PCA) of hu-man thyroid cancer cell line FRO was measured by qRT -PCR.Results:Paeonol could inhibit the growth of FRO to dif-ferent degree.After treated with Paeonol for 24 hours, the expression level of cancer -related lncRNA in FRO was in-creased .In addition , the lncRNA expression increased gradually with the increase of Paeonol concentration .Conclusion:Paeonol can inhibit the growth of FRO .Different concentrations of Paeonol have different effects on the changes of the ex -pressive levels of lncRNA in FRO .Traditional Chinese medicine Paeonol may influence the progression of human thyroid cancer by changing the expression levels of cancer -related lncRNA .Further investigation on the mechanism is needed .关键词
中药/丹皮酚/lncRNA/甲状腺癌Key words
Chinese medicine/Paeonol/lncRNA/Thyroid cancer分类
医药卫生引用本文复制引用
相萍萍,许楠,陆澄..丹皮酚对甲状腺未分化癌 FRO细胞相关 lncRNA表达的影响[J].中医药学报,2015,(5):27-30,4.基金项目
国家自然科学基金面上项目 （）
