组织工程与重建外科杂志Issue(5)：301-304,4.DOI:10.3969/j.issn.1673-0364.2015.05.004
新型复合纤维蛋白胶的磷酸钙骨水泥的生物安全性研究
Biocompatibility and Biosafety Research of New Compound of Fibrin Glue and Calcium Phosphate Bone Cement
丁超 1李奇 1林荔军 1孙永建1
作者信息
- 1. 510900 广东省从化市 南方医科大学第五附属医院骨科
- 折叠
摘要
Abstract
Objective To explore the biocompatibility and biosafety of new compound of fibrin glue and calcium phosphate bone cement, and to investigate the clinical feasibility for bone reconstruction. Methods The new compound of fibrin glue and calcium phosphate bone cement was prepared and the extract liquid was obtained. The acute toxicity test, hemolysis test, micronucleus test, the cytotoxic test were used for the biocompatibility and biosafety evaluation of the new compound. Results The CPBC extract liquid did not cause acute toxicity in mice; No hemolytic reaction was observed in experimental groups by visual inspection and the hemolytic rate was less than 5%; Micronucleus test showed no significant differences between experimental group and negative control group; The extract liquid had no significant impact on growth and differentiation of mice MC3T3 osteoblasts, and the cell toxicity classification was class I. Conclusion The new compound of fibrin glue and calcium phosphate bone cement have good biocompatibility and biosafety.关键词
磷酸钙骨水泥/纤维蛋白胶/生物相容性/生物安全性Key words
Calcium phosphate bone cement/Fibrin glue/Biocompatibility/Biosafety分类
医药卫生引用本文复制引用
丁超,李奇,林荔军,孙永建..新型复合纤维蛋白胶的磷酸钙骨水泥的生物安全性研究[J].组织工程与重建外科杂志,2015,(5):301-304,4.
