北京中医药大学学报Issue(11)：789-792,4.DOI:10.3969/j.issn.1006-2157.2015.11.016
电针“百会”“足三里”穴对 IBS 模型大鼠行为及肠道 NK1受体 mRNA 表达的影响
Electro-acupuncturing at “Baihui”point and “Zusanli”point on beha-vior and mRNA expression of intestinal NK1 receptor in rats with irrita-ble bowel syndrome
摘要
Abstract
Objective To observe the effects of electro-acupuncturing (EA)at “Baihui”(DU20)and“Zusanli”(ST36)on the visceral sensitivity and emotional and psychological behavior of the irritable bowel syndrome (IBS)model rats,and to explore the double adjustment of electro-acupuncture on chron-ic visceral pain with emotional and psychological dysfunction.Methods Wistar immature rats were ran-domly divided into normal group,model group and electro-acupuncture group.The IBS model was in-duced by mechanical colorectal irritation of acetic acid combined with maternal separation in the postnatal period.Rats of normal group and model group underwent no intervention while those of electro-acupunc-ture group were needled at “Baihui”and “Zusanli”every other day for ten days.The visceral sensitivity was evaluated and the open-filed test was used,and the mRNA of neurokinin-1(NK1)receptor was de-tected by using RT-PCR.Results The treatment of acupuncture reduced significanty the visceral sensi-tivity,crossing activity and vertical activity in open field test,and the mRNA expression of NK1.Con-clusion The double adjustment of electro-acupuncturing at “Baihui”and “Zusanli”on chornic visceral sensitivity with emotional and psychological dysfunction was proved.关键词
肠易激综合征/电针/内脏敏感性/情绪/NK1 受体/大鼠Key words
irritable bowel syndrome/electro-acupuncture/visceral sensitivity/emotion/neurokinin-1 receptor/rats分类
医药卫生引用本文复制引用
赵雅芳,郭孟玮,王顺,杨帅,冯潇潇,任晓暄..电针“百会”“足三里”穴对 IBS 模型大鼠行为及肠道 NK1受体 mRNA 表达的影响[J].北京中医药大学学报,2015,(11):789-792,4.基金项目
国家自然科学基金资助项目 （）
