福建农林大学学报（自然科学版）2015，Vol.44Issue(6)：561-566,6.DOI:10.13323/j.cnki.j.fafu(nat.sci.).2015.06.001
革兰氏阴性细菌外膜蛋白耐药功能及其抑菌策略研究进展
An review on the antibiotics resistance function of outer membrane protein in gram-negative bacterial and related antimicrobial strategies
摘要
Abstract
The emergence of bacterial resistance to drug use has posed serious problem worldwide. Generally, the drug resistance ca-pability of gram-negative bacteria is stronger than that of gram-positive, which is partially attributed to the antibiotics resistance of the outer membrane proteins ( OMPs) . It is well known that the specific OMPs efflux antibiotics out or inhibits uptakes of antibiot-ics, while the regulation mechanism remains uncertain. With the development of modern science and technology, especially the ap-plication of structure biology, molecular biology and proteomics, many progressive studies have unveiled the mechanisms underlying the antibiotic resistance of OMPs. This review focuses on the recent advances in the structure and antibiotic resistance mechanisms of OMP, which provides helpful insight into manufacture of new OMPs-targeting antimicrobial drug.关键词
外膜蛋白/耐药机制/药物主动转运系统/抑菌策略Key words
outer membrane protein/antibiotics resistance mechanism/efflux pump system/antimicrobial strategy分类
生物科学引用本文复制引用
李碗芯,孙莉娜,林向民..革兰氏阴性细菌外膜蛋白耐药功能及其抑菌策略研究进展[J].福建农林大学学报（自然科学版）,2015,44(6):561-566,6.基金项目
国家自然科学基金项目(31470238、31200105). （31470238、31200105）
