临床与病理杂志Issue(11)：1943-1947,5.DOI:10.3978/j.issn.2095-6959.2015.11.018
血浆WIF-1 DNA甲基化与肝癌患者临床特征和预后的关系
Expression and clinical significance of WIF-1 DNA methylation in hepatic cancer
摘要
Abstract
Objectives:Our topic is to analysis the relationship between the promoter region WIF-1 DNA methylation status and the characteristics in hepatic cancer, and explores the role of WIF-1 DNA methylation in the occurrence and metastasis of hepatic cancer.Methods: hTe methylation speciifc-PCR (MSP) was used to detect the tumor suppressor gene WIF-1 methylation in the above-mentioned tissues. To explore the role of them in the occurrence and development of hepatic cancer, and the relationship associated with the clinical relevant factors. Discussion the relationship between the methylation status with clinicopathologic factors (sex, age, AFP, differentiation degree, clinical stage) and progression-free survival (PFS) as well as overall survival (OS) were analyzed.Results: hTe methylation status of WIF-1 in plasma of hepatic cancer patients were 31.4%. hTere were no correlations among the WIF-1 methylation status in hepatic cancer plasma and patient’s sex, age, cirrhosis and anti-HBs (P>0.05), but correlate with degree of differentiation TNM staging. Multivariate analysis indicated that besides tumor size,methylation status is also an independent risk factor inlfuencing recurrence, also independently correlated with TTP and OS in hepatic patients.Conclusion: WIF-1 methylation is independently correlated with TTP and OS in hepatic cancer patients, and combined detection of methylation of gene show great importance in the ifeld of judging the prognosis. Tumor suppressor gene WIF-1 methylation is an early molecular event of hepatic cancer.关键词
甲基化/WIF-1/肝细胞癌/预后Key words
methylation/WIF-1/prognosis/hepatocellular carcinoma引用本文复制引用
刘艳,刘凡,沈浮,茅国新,袁心露..血浆WIF-1 DNA甲基化与肝癌患者临床特征和预后的关系[J].临床与病理杂志,2015,(11):1943-1947,5.基金项目
苏省卫生厅科研项目(H200957)。hTis work was supported by the Department of Health of Jiangsu Province (H200957), P. R. China （H200957）
