国际病理科学与临床杂志Issue(11)：2018-2022,5.DOI:10.3978/j.issn.2095-6959.2015.11.032
去泛素化酶影响低氧诱导因子-1α泛素化过程的研究进展
Research progression in deubiquitination enzymes in the ubiquitination of hypoxia-inducible factor-1α
摘要
Abstract
Hypoxia-inducible factor -1α (HIF-1α) is a kind of oxygen-dependent nuclear transcriptional factors. Under hypoxic conditions, HIF-1α accumulates in cytoplasm and then transfers into nucleus to promote transcription and expression of its target genes, enhancing proliferation, invasion and metastasis of tumors; while under normoxic conditions, the synthesis and degradation of HIF-1α protein remain relatively balanced. HIF-1α is mainly degraded via the ubiquitin-proteasome pathway. Numerous studies showed that ubiquitination enzymes not only effectively reverses the ubiquitin-proteasome degradation process of HIF-1α, but also promote the tumor progress through various ways. This review focus on the mechanisms of deubiquitination enzymes affecting ubiquitination of HIF-1α.关键词
低氧诱导因子-1α/泛素化/去泛素化酶/去泛素化Key words
hypoxia-inducible factor-1α/ubiquitination/ubiquitination enzymes引用本文复制引用
孙微(综述),师永红(校审)..去泛素化酶影响低氧诱导因子-1α泛素化过程的研究进展[J].国际病理科学与临床杂志,2015,(11):2018-2022,5.基金项目
国家自然科技基金(81360395)。hTis work was supported by National Natural Science Foundation of China (81360395) （81360395）
