军事医学Issue(11)：825-830,6.DOI:10.7644/j.issn.1674-9960.2015.11.004
我国携带 NDM-1基因耐药菌流行现况分析
Epidemiological analysis of NDM-1-positive bacteria in China
摘要
Abstract
Objective To analyze the epidemiological characteristic of New Delhi metallo-β-lactamase (NDM)-1-positive bacteria in China and explore its mechanism of drug-resistance.Methods The published papers from 2010 to 2015 about domestic blaNDM-1 were collected and analyzed according to the bacteria species,regional distribution,NDM-1-positive bacteria,infectious source,drug-resistance spectra and transfer mechanism.Results NDM-1-positive bacteria were isola-ted from 25 provinces (municipalities)in China,Guangdong Province was predominant and accounted for 39.49%(P <0.05).The number of Klebsiella pneumoniae and Enterobacter cloacae were predominant in the NDM-1-positive bacteria (P <0.05).Number of patients under the age of ten and among 60 -80 years which infected by NDM-1-positive bacteria were predominant of all the reported patients(P <0.05).The most kinds of samples and diseases were sputum sample (P <0.05)and pulmonary diseases(P <0.05).NDM-1-positive bacteria which found in China had the lowest resistance to amikacin and tigecycline accounted for 7.69% and 2.33%(P <0.05).Conclusion Antibiotic resistant bacteria with NDM-1 resistant gene have become a global public health problem,and significant difference among age,districts and sources,which need active surveillance and more studies to find how it happens and epidemic in the future.关键词
NDM-1/流行病学特征/耐药谱/转移机制Key words
NDM-1/epidemiology characteristic/drug-resistance spectrum/transfer mechanism分类
医药卫生引用本文复制引用
王盛书,孙金柱,苏文莉,胡智,杨建鹏,王勇..我国携带 NDM-1基因耐药菌流行现况分析[J].军事医学,2015,(11):825-830,6.基金项目
国家自然科学基金资助项目（81373077）；国家传染病重大专项资助项目 （）
